A GAME THEORETIC MODEL OF COOPERATION AND NON-COOPERATION FOR SOCCER PLAYING ROBOTS

Abstract: This paper proposes a model which combines cooperative and noncooperative behaviors among autonomous mobile robots. This problem is well demonstrated by the Soccer playing robots, which consists of two sub-games, namely a non-cooperative game between the teams, and a cooperative game among the players of the same team. Game theory is used for modeling these games. The model consists of two layers, the first for the non-cooperative game which feeds its output to the cooperative game in the second layer. Fuzzy logic is used to evaluate the utility functional. The model is implemented using a soccer playing robot simulator

Automated generation of constructive ordering heuristics for educational timetabling

Construction heuristics play an important role in solving combinatorial optimization problems. These heuristics are usually used to create an initial solution to the problem which is improved using optimization techniques such as metaheuristics. For examination timetabling and university course timetabling problems essentially graph colouring heuristics have been used for this purpose. The process of deriving heuristics manually for educational timetabling is a time consuming task. Furthermore, according to the no free lunch theorem different heuristics will perform well for different problems and problem instances. Hence, automating the induction of construction heuristics will reduce the man hours involved in creating such heuristics, allow for the derivation of problem specific heuristics and possibly result in the derivation of heuristics that humans have not thought of. This paper presents generation construction hyper-heuristics for educational timetabling. The study investigates the automatic induction of two types of construction heuristics, namely, arithmetic heuristics and hierarchical heuristics. Genetic programming is used to evolve arithmetic heuristics. Genetic programming, genetic algorithms and the generation of random heuristic combinations is examined for the generation of hierarchical heuristics. The hyper-heuristics generating both types of heuristics are applied to the examination timetabling and the curriculum based university course timetabling problems. The evolved heuristics were found to perform much better than the existing graph colouring heuristics used for this domain. Furthermore, it was found that the while the arithmetic heuristics were more effective for the examination timetabling problem, the hierarchical heuristics produced better results than the arithmetic heuristics for the curriculum based course timetabling problem. Genetic algorithms proved to be the most effective at inducing hierarchical heuristics

Discovering beneficial cooperative structures for the automatic construction of heuristics

The current research trends on hyper-heuristics design have sprung up in two different flavours: heuristics that choose heuristics and heuristics that generate heuristics. In the latter, the goal is to develop a problem-domain independent strategy to automatically generate a good performing heuristic for specific problems, that is, the input to the algorithm are problems and the output are problem-tailored heuristics. This can be done, for example, by automatically selecting and combining different low-level heuristics into a problemspecific and effective strategy. Thus, hyper-heuristics raise the level of generality on automated problem solving by attempting to select and/or generate tailored heuristics for the problem in hand. Some approaches like genetic programming have been proposed for this. In this paper, we report on an alternative methodology that sheds light on simple methodologies that efficiently cooperate by means of local interactions. These entities are seen as building blocks, the combination of which is employed for the automated manufacture of good performing heuristic search strategies.We present proof-of-concept results of applying this methodology to instances of the well-known symmetric TSP. The goal here is to demonstrate feasibility rather than compete with state of the art TSP solvers. This TSP is chosen only because it is an easy to state and well known problem

Using Genetic Improvement and Code Transplants to Specialise a C++ Program to a Problem Class

Genetic Improvement (GI) is a form of Genetic Programming that improves an existing program. We use GI to evolve a faster version of a C++ program, a Boolean satisfiability (SAT) solver called MiniSAT, specialising it for a particular problem class, namely Combinatorial Interaction Testing (CIT), using automated code transplantation. Our GI-evolved solver achieves overall 17 percent improvement, making it comparable with average expert human performance. Additionally, this automatically evolved solver is faster than any of the human-improved solvers for the CIT problem

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD

Clinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry

Background: Clinical complexity is increasingly prevalent among patients with atrial fibrillation (AF). The ‘Atrial fibrillation Better Care’ (ABC) pathway approach has been proposed to streamline a more holistic and integrated approach to AF care; however, there are limited data on its usefulness among clinically complex patients. We aim to determine the impact of ABC pathway in a contemporary cohort of clinically complex AF patients. Methods: From the ESC-EHRA EORP-AF General Long-Term Registry, we analysed clinically complex AF patients, defined as the presence of frailty, multimorbidity and/or polypharmacy. A K-medoids cluster analysis was performed to identify different groups of clinical complexity. The impact of an ABC-adherent approach on major outcomes was analysed through Cox-regression analyses and delay of event (DoE) analyses. Results: Among 9966 AF patients included, 8289 (83.1%) were clinically complex. Adherence to the ABC pathway in the clinically complex group reduced the risk of all-cause death (adjusted HR [aHR]: 0.72, 95%CI 0.58–0.91), major adverse cardiovascular events (MACEs; aHR: 0.68, 95%CI 0.52–0.87) and composite outcome (aHR: 0.70, 95%CI: 0.58–0.85). Adherence to the ABC pathway was associated with a significant reduction in the risk of death (aHR: 0.74, 95%CI 0.56–0.98) and composite outcome (aHR: 0.76, 95%CI 0.60–0.96) also in the high-complexity cluster; similar trends were observed for MACEs. In DoE analyses, an ABC-adherent approach resulted in significant gains in event-free survival for all the outcomes investigated in clinically complex patients. Based on absolute risk reduction at 1 year of follow-up, the number needed to treat for ABC pathway adherence was 24 for all-cause death, 31 for MACEs and 20 for the composite outcome. Conclusions: An ABC-adherent approach reduces the risk of major outcomes in clinically complex AF patients. Ensuring adherence to the ABC pathway is essential to improve clinical outcomes among clinically complex AF patients

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P <.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes